Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jan 8;43(2):732–744. doi: 10.1093/nar/gku1305

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 5. — Identification of individual-specific DMRs (inDMRs). (A) Scatterplots depicting the averaged read depths for each individual versus the mean of the other two individuals. Individual-specific hyper- and hypomethylated DMRs are indicated for each individual (red and blue points, respectively). The number of hypermethylated (red) and hypomethylated (blue) DMRs are indicated for each comparison. (B) The left panel depicts the MAP-seq profiles for each individual (Individual A, darkblue; Individual B, red; Individual C, orange) at the ZFP57 locus (chr6 29746600–29766600; hg18 genome build). The right panel shows the bisulfite sequencing result confirming that Individual C has reduced methylation levels relative to Individuals A and B as predicted by the MAP-seq analysis. (C) The left panel depicts the MAP-seq profiles for each individual (Individual A, darkblue; Individual B, red; Individual C, orange) at the PCDHB6 locus (chr5 140505700–140520700; hg18 genome build). The right panel shows the bisulfite sequencing result confirming that the methylation level is the highest in Individual A and lowest in C as predicted by the MAP-seq analysis. The layout for (B) and (C) are presented as for Figure 2B.