Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Dec 24;43(2):875–892. doi: 10.1093/nar/gku1307

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 11. — Two pathways exist for the short patch repair of SSBs. In the canonical pathway (PARP1 dependent) (A) PARP1 senses DNA damage and rapidly catalyzes the formation of PAR residues that allow for (B) chromatin expansion which in turn facilitates (C) the recruitment of downstream repair proteins. In the second pathway (PARP1 independent) (D) XRCC1–LIG3 complex continuously scans the DNA, upon sensing an interruption (via LIG3), (E) the complex is capable of causing a localized nucleosomal disruption (dependent on LIG3) (42), and the scaffold XRCC1 is capable of (F) loading downstream repair factors, PNKP and Polβ, and then repair continues as previously described (G).