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PARP1 inhibition and the retention of SSBR proteins at sites of DNA damage. FRAP analysis on HeLa cells expressing GFP-tagged (A) XRCC1, (B) PNKP and (C) LIG3, respectively, before and after DNA damage with 10 mM hydrogen peroxide in the absence and presence of 2 μM AG14361 as described in the Materials and Methods section. ‘Prebleach’ indicates no photobleaching and ‘Bleach’ is the 0-s time point. For recovery curves, error bars represent SEM; n = 24.
