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. 2015 Jan 7;43(2):960–972. doi: 10.1093/nar/gku1358

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Bcl2 directly inhibits Mre11/DNA binding in vitro. (A) ³²P-labelled 3′ overhanging DNA duplexes were incubated with increasing concentrations of Mre11. Mre11/DNA binding was analyzed by EMSA as described in ‘Materials and Methods’ section. (B) Effect of increasing concentrations of purified WT Bcl2 protein on Mre11/DNA binding was analyzed by EMSA. (C) Effect of various BH deletion Bcl2 mutant proteins on Mre11/DNA binding was analyzed by EMSA.