TABLE 1.

List of inhibitors, target molecule(s), and concentrations used in rickettsial invasion bioassays

Inhibitor	Tick target molecule(s)	Concentrations used (μM)
Zygosporium mansonii cytochalasin Db	Actin polymerization	1, 10, 100
CK-666b	Arp2/3 complex	5, 50, 500
187-1	N-WASP	1, 10, 100
Clostridium difficile toxin Ba	Rho GTPases (Rho, Cdc42, and Rac)	0.00001, 0.0001, 0.001
Rac1 inhibitora	Rac1	10, 100, 1000
Genisteinb	PTKs	5, 50, 500
PP2b	Src family PTKs	2.5, 25, 250
FAK inhibitor I	FAK	5, 50, 500
PI3-kinase inhibitor XI, HWT	PI3-kinase	5, 50, 500

^aDissolved in complete L15C medium, not 1% DMSO.

^bKnown activity in Drosophila cell line (9).