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Deletion of acuK and/or acuM attenuates virulence in the mouse model of invasive pulmonary aspergillosis. Shown are survival times of mice that were immunosuppressed with cortisone acetate and then infected with the indicated A. fumigatus strains in an aerosol chamber. Results in both panels are from independent experiments using 7 or 8 mice per strain. *, P ≤ 0.02 compared to the wild-type strain; †, P < 0.001 compared to the ΔacuK+acuK complemented strain.
