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B. abortus mouse infection upregulates the production of LTB4 and LXA4 in a 5-LO-dependent manner. The blood of 129 Sv/Ev and 5-LO KO mice infected with B. abortus 2308 (1 × 106/mouse) was collected 1, 3, and 6 weeks after infection for the measurement of LTB4 (A) and LXA4 (B) in the serum by ELISA. Results are expressed as means ± standard deviations and are representative of 3 independent experiments (n = 3). *, P ≤ 0.05 compared to 5-LO KO mice.
