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. 2015 Jan 20;112(4):704–713. doi: 10.1038/bjc.2014.623

Figure 1.

Figure 1

Immunohistochemical (IHC) and fluorescence in situ hybridisation (FISH) analyses of representative actinin-4 protein expression and ACTN4 copy number, respectively, in LAPC biopsy specimens. (A–F) Immunohistochemical analysis of actinin-4 protein expression. Representative cases of no expression (A, B), weak expression (C, D) and strong expression (E, F) of actinin-4 protein in LAPC cells. (A), (C) and (E) are low-magnitude images. (B), (D) and (F) are high-magnitude images of regions of (A), (C) and (E), respectively. (G, H) Fluorescence in situ hybridisation analysis of representative cases with a copy number increase (CNI) in ACTN4.