Table 4. Univariate and multivariate Cox proportional hazard models to predict survival of patients with locally advanced pancreatic cancer receiving chemotherapy or chemoradiotherapy.
|
Univariate analysis |
Multivariate analysis |
|||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
|
Median age, years (63.0) | ||||||
| <63.0/⩾63.0 |
0.959 |
0.624–1.474 |
0.8498 |
|
|
|
|
Gender | ||||||
| Male/female |
0.802 |
0.519–1.249 |
0.334 |
|
|
|
|
PS | ||||||
| 0/1 and 2 |
1.126 |
0.697–1.819 |
0.6270 |
|
|
|
|
Median tumour size, mm (37.4) | ||||||
| <37.4 mm/⩾37.4 mm |
1.066 |
0.665–1.709 |
0.7902 |
|
|
|
|
Lymph node metastasis | ||||||
| Negative/positive |
1.606 |
1.008–2.560 |
0.0463 |
1.199 |
0.7654–1.978 |
0.0740 |
|
Location of the tumour | ||||||
| Head/body or tail of pancreas |
0.764 |
0.492–1.185 |
0.2294 |
|
|
|
|
CA19-9 | ||||||
| <1000/⩾1000 U ml−1 |
2.354 |
1.479–3.761 |
0.0003 |
2.325 |
1.416–3.818 |
0.0009 |
|
Actinin-4 IHC | ||||||
| Negative/positive |
1.526 |
0.922–2.528 |
0.1004 |
|
|
|
|
ACTN4 FISH | ||||||
| NCN/CNI | 2.531 | 1.394–4.597 | 0.0023 | 2.645 | 1.439–4.861 | 0.0017 |
Abbreviations: ACTN4=actinin-4; 95% CI=95% confidence interval; CNI=copy number increase; FISH=fluorescence in situ hybridisation; HR=hazard ratio; IHC=immunohistochemistry; NCN=normal copy number; PS=Eastern Cooperative Oncology Group Performance Status. Bold entries indicate statistically significance.