Table 2. Survival estimates by patient characteristics.
N Patients | N Events | 5-year overall survival estimate (95% CI) | P-value | N Events | 5-year relapse-tree survival estimate (95% CI) | P-value | |
---|---|---|---|---|---|---|---|
All patients |
589 |
38 |
0.93 (0.9, 0.95) |
|
61 |
0.87 (0.84, 0.9) |
|
Year of diagnosis | |||||||
2001–2006 | 142 | 14 | 0.92 (0.86, 0.96) | 19 | 0.88 (0.82, 0.93) | ||
2007–2012 |
447 |
24 |
0.93 (0.89, 0.95) |
0.60 |
42 |
0.86 (0.8, 0.9) |
0.64 |
Age (years) | |||||||
Age≤50 | 293 | 19 | 0.93 (0.88, 0.96) | 30 | 0.87 (0.82, 0.91) | ||
Age>50 |
296 |
19 |
0.92 (0.88, 0.95) |
0.78 |
31 |
0.87 (0.82, 0.91) |
0.80 |
Race/ethnicity | |||||||
White | 344 | 23 | 0.92 (0.88, 0.95) | 33 | 0.89 (0.85, 0.92) | ||
Black | 73 | 6 | 0.89 (0.77, 0.95) | 13 | 0.72 (0.55, 0.84) | ||
Hispanic | 116 | 4 | 0.98 (0.92, 0.99) | 7 | 0.92 (0.83, 0.96) | ||
Other |
56 |
5 |
0.87 (0.71, 0.95) |
0.39 |
8 |
0.84 (0.71, 0.92) |
0.03 |
Clinical stage | |||||||
I–II | 301 | 17 | 0.93 (0.89, 0.96) | 22 | 0.9 (0.85, 0.94) | ||
III |
282 |
20 |
0.92 (0.87, 0.95) |
0.42 |
38 |
0.84 (0.79, 0.88) |
0.01 |
Histology | |||||||
Ductal | 543 | 34 | 0.93 (0.9, 0.95) | 54 | 0.88 (0.84, 0.91) | ||
Other |
46 |
4 |
0.91 (0.74, 0.97) |
0.56 |
7 |
0.82 (0.64, 0.92) |
0.26 |
Nuclear grade | |||||||
1–2 | 123 | 7 | 0.93 (0.84, 0.97) | 14 | 0.86 (0.76, 0.92) | ||
3 |
452 |
30 |
0.93 (0.89, 0.95) |
0.57 |
45 |
0.88 (0.84, 0.91) |
0.71 |
Lymphovascular invasion | |||||||
Negative | 479 | 24 | 0.94 (0.91, 0.96) | 37 | 0.9 (0.87, 0.93) | ||
Positive |
110 |
14 |
0.86 (0.76, 0.92) |
0.002 |
24 |
0.72 (0.6, 0.81) |
<0.0001 |
Hormone receptor status | |||||||
Negative | 236 | 18 | 0.92 (0.86, 0.95) | 24 | 0.88 (0.82, 0.92) | ||
Positive |
348 |
20 |
0.93 (0.89, 0.96) |
0.53 |
36 |
0.87 (0.82, 0.91) |
0.77 |
Pathologic complete response | |||||||
No | 386 | 33 | 0.9 (0.85, 0.93) | 54 | 0.83 (0.78, 0.87) | ||
Yes |
203 |
5 |
0.98 (0.93, 0.99) |
0.002 |
7 |
0.95 (0.9, 0.98) |
<0.0001 |
Adjuvant trastuzumab | |||||||
No | 109 | 11 | 0.91 (0.84, 0.95) | 12 | 0.92 (0.85, 0.96) | ||
Yes |
480 |
27 |
0.93 (0.9, 0.95) |
0.97 |
49 |
0.85 (0.8, 0.89) |
0.33 |
Adjuvant radiation | |||||||
No | 125 | 8 | 0.94 (0.86, 0.97) | 10 | 0.89 (0.79, 0.95) | ||
Yes |
464 |
30 |
0.92 (0.89, 0.95) |
0.69 |
51 |
0.87 (0.83, 0.9) |
0.63 |
Adjuvant endocrine therapy | |||||||
No | 301 | 23 | 0.91 (0.87, 0.94) | 31 | 0.87 (0.82, 0.91) | ||
Yes | 288 | 15 | 0.94 (0.89, 0.96) | 0.17 | 30 | 0.87 (0.82, 0.91) | 0.84 |
Abbreviation: CI=confidence interval.