Table 2B. Prognostic values of Osteopontin staining: predictive value of OPNc, Osteopontin–exon 4 (exon 4) or pan-OPN immunohistochemistry for patient survival, split up according to nucl.int., nucl.per., cyt.int. and cyt.per.
| |
|
95% CI |
||
|---|---|---|---|---|
| Odds ratio | Significance | Lower | Upper | |
|
Polish cohort | ||||
| Exon 4 cyt.int. | 1.88 | <0.001 | 1.40 | 2.56* |
| Exon 4 cyt.per. | 0.99 | 0.540 | 0.98 | 1.01 |
| OPNc nucl.int. | 1.52 | 0.001 | 1.19 | 1.95* |
| OPNc nucl.per. |
1.00 |
0.684 |
0.99 |
1.01 |
|
Swedish cohort | ||||
| Pan-OPN nucl.int. | 0.72 | 0.066 | 0.51 | 1.02 |
| Pan-OPN nucl.per. | 1.00 | 0.732 | 0.99 | 1.01 |
| Pan-OPN cyt.int. | 1.00 | 0.997 | 0.70 | 1.43 |
| Pan-OPN cyt.per. | 0.99 | 0.059 | 0.98 | 1.00 |
| OPNc cyt.int. | 1.38 | 0.058 | 0.99 | 1.93 |
| OPNc cyt.per. | 0.99 | 0.374 | 0.98 | 1.01 |
| OPNc nucl.int. | 1.47 | 0.007 | 1.11 | 1.94* |
| OPNc nucl.per. |
1.00 |
0.393 |
0.99 |
1.00 |
|
Combined | ||||
| OPNc nucl.int. | 1.50 | <0.001 | 1.25 | 1.81* |
| OPNc nucl.per. | 1.00 | 0.290 | 1.00 | 1.01 |
Abbreviations: CI=confidence interval; cyt.int.=cytosolic intensity; cyt.per.=cytosolic per cent positivity; nucl.int.=nuclear intensity; nucl.per.=nuclear per cent positivity; pan-OPN=pan-Osteopontin.
The two study populations (Polish n=291, Swedish n=380) are evaluated separately (top two sections). The combined analysis (bottom section) is adjusted for group (the regression model of survival indicated that there was a group effect; the overlapping confidence intervals in the calculations for OPN nucl.int. corroborate its prognostic usefulness). Significant values are marked with an asterisk.