Table 2. Non-haematologic toxicity in first course attributed as at least possibly related to study therapy and occurring in >10% of 32 total patients.
| 555 MBq kg−1 (15 mCi kg−1; n=6) | 666 MBq kg−1 (18 mCi kg−1; n=26) | All patients (n=32) | |
|---|---|---|---|
| Grade 1 or 2 | |||
| Diarrhoea | 83 | 65 | 69 |
| Aspartate aminotransferase increased | 83 | 62 | 66 |
| Nausea | 67 | 62 | 63 |
| Alanine aminotransferase increased | 33 | 50 | 47 |
| Anorexia | 33 | 50 | 47 |
| Vomiting | 83 | 38 | 47 |
| Oral pain | 33 | 46 | 44 |
| Dry mouth | 50 | 31 | 34 |
| Alopecia | 67 | 23 | 31 |
| Fatigue | 0 | 38 | 31 |
| Constipation | 50 | 19 | 25 |
| Abdominal pain | 17 | 23 | 22 |
| Hypoalbuminemia | 33 | 19 | 22 |
| Hypokalemia | 33 | 19 | 22 |
| Hyponatremia | 0 | 27 | 22 |
| Sore throat | 0 | 23 | 19 |
| Urinary tract pain | 33 | 15 | 19 |
| Serum amylase increased | 0 | 19 | 16 |
| Alkaline phosphatase increased | 0 | 15 | 13 |
| Bone pain | 33 | 8 | 13 |
| Cough | 0 | 15 | 13 |
| Hypomagnesemia | 0 | 15 | 13 |
| Rash and other skin disorder | 0 | 15 | 13 |
| Weight loss | 33 | 8 | 13 |
| Dehydration |
0 |
8 |
6 |
| Grade 3 | |||
| Vomiting | 0 | 11 | 9 |
| Dehydration | 0 | 8 | 6 |
| Diarrhoea | 0 | 8 | 6 |
| Hyponatremia | 0 | 8 | 6 |
| Serum amylase increased | 0 | 8 | 6 |
| Anorexia | 0 | 4 | 3 |
| Hypokalemia | 0 | 4 | 3 |
| Nausea | 0 | 4 | 3 |
Values given are percentage of patients at each dose level with toxicity.