Table 5. Association of the key measures of first-course toxicity with the UGT1A1 genotype in 24 patients with available genotype data.
| UGT1A1 genotype | Diarrhoea of any grade | Diarrhoea >grade 2 | Grade 4 neutropenia | Grade 4 thrombocytopenia |
|---|---|---|---|---|
| Homozygous wild type (n=11) |
8 (73%) |
2 (18%) |
10 (91%) |
5 (45%) |
| Heterozygous UGT1A1*28 (n=8) |
5 (62%) |
0 (0%) |
5 (62%) |
2 (18%) |
| Homozygous UGT1A1*28 (n=5) | 4 (80%) | 0 (0%) | 5 (100%) | 4 (80%)* |
*P=0.14 by Fisher exact test comparing proportion with grade 4 thrombocytopenia between patients homozygous for UGT1A1*28 and patients not homozygous for UGT1A1*28.