TABLE 3.

Studies of the Cognitive Effects of Androgen Ablation Therapy in Men With Prostate Cancer

Study	No. of Participants	Timing	Results (Domain)	Results (Task-specific)
Green 200248	39 Men (ADT), 15 controls	Baseline, 6 mo	↑↓Verbal memory	48% Declined in 1 task, 14% declined in 2 tasks
Cherrier 200349	19 Men (ADT), 15 controls	Baseline, 9 mo, 12 mo	↑Verbal memory, ↓visual memory, ↓visuospatial memory	69% declined in 1 task
Almeida 200350	37 Men (ADT)	8 Assessments over 1 y	↑Verbal memory, ↑verbal memory
Salminen 200413	26 Men (ADT)	Baseline, 6 mo, 12 mo	↓Visuomotor processing, ↓reaction time, ↓working memory, ↓recall of letters, ↑object recall
Bussiere 200552	14 Men (ADT), 16 controls	Immediately, 2 min, 12 min	↓Memory retention, ↓recognition
Salminen 200551	23 Men (ADT)	Baseline, 6 mo, 12 mo	↓Verbal fluency, ↓visual recognition, ↓visual memory
Beer 200653	18 Men (ADT 1 estradiol), 18 controls (ADT only), 17 controls (healthy)	Baseline, 4 wk	↓Verbal memory, ↓psychomotor speed/processing speed
Jenkins 200554	32 Men (ADT), 25 controls	Baseline; T2, 3 mo; T3, 9 mo	↓Spatial memory, ↓spatial ability	47% Declined in 1 task
Joly 200655	57 Men (ADT), 51 controls		No differences on High-sensitivity Cognitive Screen; no differences on FACT-COG

ADT indicates androgen deprivation therapy; ↑, increase; ↓, decline; FACT-COG, Functional Assessment of Cancer Therapy-Cognitive.