Table 4.
Representation 3’UTR polymorphisms of HLA-G in HIV-1 positive mothers, N (%)
| Polymorphism | NT (n=144) |
IP-TR (n=29) |
IU-TR (n=19) |
IU2-TR (n=43) |
IP-TR vs. NT | IU-TR vs. NT | IU2-TR vs. NT | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) |
P | OR (95% CI) |
P | OR (95% CI) |
P | ||||||
|
+2961
(Indel) |
D | 166 (57.64) |
36 (62.07) |
19 (50.00) |
43 (50.00) |
1.20 (0.67- 2.14) |
0.562 | 0.73 (0.37- 1.45) |
0.388 | 0.73 (0.45- 1.19) |
0.218 |
| I | 122 (42.36) |
22 (37.93) |
19 (50.00) |
43 (50.00) |
1 | 1 | 1 | ||||
| DD | 53 (36.81) |
11 (37.93) |
6 (31.58) |
12 (27.91) |
1.61 (0.47- 5.48) |
0.564 | 0.58 (0.17- 1.97) |
0.527 | 0.58 (0.23- 1.45) |
0.344 | |
| ID | 60 (41.67) |
14 (48.28) |
7 (36.84) |
19 (44.19) |
1.81 (0.55- 5.96) |
0.414 | 0.52 (0.16- 1.69) |
0.348 | 0.81 (0.35- 1.90) |
0.668 | |
| II | 3 (21.53) |
4 (13.79) |
6 (31.58) |
12 (27.91) |
1 | 1 | 1 | ||||
|
| |||||||||||
| +3003.T/C | C | 31 (10.76) |
9 (15.52) |
1 (2.63) | 4 (4.65) | 1.52 (0.68- 3.40) |
0.366 | 0.22 (0.03- 1.69) |
0.149 | 0.40 (0.14- 1.18) |
0.095 |
| T | 257 (89.24) |
49 (84.48) |
37 (97.37) |
82 (95.35) |
1 | 1 | 1 | ||||
| CC | 4 (2.78) | 1 (3.45) | 0 (0.00) | 0 (0.00) | 1.39 (0.15- 13.1) |
1.000 | - | 1.000 | - | 0.573 | |
| TC | 23 (15.97) |
7 (24.14) |
1 (5.26) | 4 (9.30) | 1.69 (0.36- 4.45) |
0.418 | 0.28 (0.03- 2.22) |
0.311 | 0.52 (0.17- 1.60) |
0.329 | |
| TT | 117 (81.25) |
21 (72.41) |
18 (94.74) |
39 (90.70) |
1 | 1 | 1 | ||||
|
| |||||||||||
| +3010.C/G | G | 100 (34.72) |
22 (37.93) |
15 (39.47) |
26 (30.23) |
1.14 (0.64- 2.06) |
0.653 | 1.23 (0.61- 2.45) |
0.590 | 0.81 (0.48- 1.37) |
0.516 |
| C | 188 (65.28) |
36 (62.07) |
23 (60.53) |
60 (69.77) |
1 | 1 | 1 | ||||
| GG | 23 (15.97) |
4 (13.79) |
5 (26.32) |
5 (11.63) | 1.06 (0.31- 3.66) |
1.000 | 1.61 (0.49- 5.32) |
0.518 | 0.66 (0.22- 1.95) |
0.609 | |
| CG | 54 (37.50) |
14 (48.28 |
5 (26.32) |
16 (37.21) |
1.58 (0.66- 3.76) |
0.379 | 0.69 (0.22- 2.18) |
0.582 | 0.90 (0.43- 1.89) |
0.853 | |
| CC | 67 (46.53) |
11 (37.93) |
9 (47.37) |
22 (51.16) |
1 | 1 | 1 | ||||
|
| |||||||||||
| +3027.C/A | A | 1 (0.35 | 0 (0.00) | 0 (0.00) | 0 (0.00) | - | 1.000 | - | 1.000 | - | 1.000 |
| C | 287 (99.65) |
58 (100.00) |
38 (100.00) |
86 (100.00) |
1 | 1 | 1 | ||||
| AA | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | - | 1.000 | - | 1.000 | - | 1.000 | |
| CA | 1 (0.69) | 0 (0.00) | 0 (0.00) | 0 (0.00) | - | 1.000 | - | 1.000 | - | 1.000 | |
| CC | 143 (99.31) |
29 (100.00) |
19 (100.00) |
43 (100.00) |
1 | 1 | 1 | ||||
|
| |||||||||||
| +3032.G/C | C | 4 (1.39) | 1 (1.72) | 1 (2.63) | 2 (2.33) | 1.00 (0.11- 8.66) |
1.000 | 1.52 (0.17- 13. 5) |
1.000 | 1.34 (0.26- 7.07) |
1.000 |
| G | 284 (98.61) |
57 (98.28) |
37 (97.37) |
84 (97.67) |
1 | 1 | 1 | ||||
| CC | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | - | 1.000 | - | 1.000 | - | 1.000 | |
| GC | 4 (2.78 | 1 (3.45) | 1 (5.26) | 2 (4.65) | 1.67 (0.16- 16.6) |
1.000 | 2.59 (0.26- 26.4) |
0.396 | 2.28 (0.37- 14.1) |
0.591 | |
| GG | 140 (97.22) |
28 (96.55) |
18 (94.74) |
41 (95.35) |
1 | 1 | 1 | ||||
|
| |||||||||||
| +3035.C/T | C | 263 (91.32 |
53 (91.38) |
34 (89.47) |
78 (90.70 |
1.01 (0.37- 2.75) |
1.000 | 0.81 (0.26- 2.46) |
0.760 | 0.93 (0.40- 2.14) |
1.000 |
| T | 25 (8.68) |
5 (8.62) | 4 (10.53) |
8 (9.30) | 1 | 1 | 1 | ||||
| CC | 121 (84.03) |
24 (82.76) |
15 (78.95 |
35 (81.40) |
- | 1.000 | - | 1.000 | - | 1.000 | |
| CT | 21 (14.58) |
5 (17.24) |
4 (21.05) |
8 (18.60) |
- | 1.000 | - | 1.000 | - | 1.000 | |
| TT | 2 (1.39) |
0 (0.00) |
0 (0.00) |
0 (0.00) |
1 | 1 | 1 | ||||
|
| |||||||||||
| +3142.G/C | C | 100 (34.72) |
22 (37.93) |
15 (39.47) |
26 (30.23) |
1.14 (0.64- 2.06) |
0.653 | 1.23 (0.61- 2.45) |
0.590 | 0.81 (0.48- 1.37) |
0.516 |
| G | 188 (65.28) |
36 (62.07) |
23 (60.53) |
60 (69.77) |
1 | 1 | 1 | ||||
| CC | 23 (15.97) |
4 (13.79) |
5 (26.32) |
5 (11.63) |
1.06 (0.31- 3.65) |
1.000 | 1.61 (0.49- 5.33) |
0.518 | 0.66 (0.22- 1.95) |
0.609 | |
| GC | 54 (37.50) |
14 (48.28) |
5 (26.32) |
16 (37.21) |
1.58 (0.66- 3.76) |
0.379 | 0.68 (0.21- 2.18) |
0.582 | 0.90 (0.43- 1.89) |
0.853 | |
| GG | 67 (46.53) |
11 (37.93) |
9 (47.37) |
22 (51.16) |
1 | 1 | 1 | ||||
|
| |||||||||||
| +3187.A/G | G | 31 (10.76) |
6 (10.34) |
10 (26.32) |
14 (16.28) |
0.96 (0.37- 2.41) |
1.000 | 2.96 (1.31- 6.67) |
0.011 | 1.61 (0.81- 3.19) |
0.187 |
| A | 257 (89.24) |
52 (89.66) |
28 (73.68) |
72 (83.72) |
1 | 1 | 1 | ||||
| GG | 2 (1.39) | 0 (0.00) | 3 (15.79) |
3 (6.98) | - | 1.000 | 14.4 (2.18- 94.7) |
0.011 | 5.39 (0.86- 33.7) |
0.080 | |
| AG | 27 (18.75) |
6 (20.69) |
4 (21.05) |
8 (18.60) |
1.11 (0.41- 2.99) |
1.000 | 1.42 (0.42- 4.74) |
0.740 | 1.06 (0.44- 2.57) |
1.000 | |
| AA | 115 (79.86) |
23 (79.31) |
12 (63.16) |
32 (74.42) |
1 | 1 | 1 | ||||
|
| |||||||||||
| +3196.C/G | G | 97 (33.68) |
17 (29.31) |
15 (39.47) |
35 (40.70) |
0.82 (0.44- 1.51) |
0.545 | 1.28 (0.64- 2.57) |
0.586 | 1.35 (0.82- 2.21) |
0.249 |
| C | 191 (66.32) |
41 (70.69) |
23 (60.53) |
51 (59.30) |
1 | 1 | 1 | ||||
| GG | 18 (12.50) |
2 (6.90) | 4 (21.05) |
7 (16.28) |
0.52 (0.11- 2.48) |
0.514 | 1.81 (0.48- 6.68) |
0.464 | 1.68 (0.60- 4.76) |
0.399 | |
| CG | 61 (42.36) |
13 (44.83) |
7 (36.84) |
21 (48.84) |
0.98 (0.43- 2.27) |
1.000 | 0.93 (0.32- 2.73) |
1.000 | 1.49 (0.71- 3.16) |
0.347 | |
| CC | 65 (45.14) | 14 (48.28) | 8 (42.11) | 15 (34.88) | 1 | 1 | 1 | ||||
NT: HIV-1 nontransmitting mother; IP-TR: intrapartum HIV-1 transmitting mother; IU-TR: in utero HIV-1 transmitting mother; IU2-TR: enriched group of presumed in utero transmitting mothers. Highlighted and bold P values indicate significant differences (P<0.05) and bold P values indicate trends (P<0.090).