Table 7.
Logistic regression analysis, adjustments made for maternal factors that influence MTCT of HIV-1
| Allele/genotype | Association | Unadjusted | Adjusted mVL | Adjusted mNVP | Adjusted Infant KIR2DS4-v |
||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) |
P | OR (95% CI) |
P | OR (95% CI) |
P | OR (95% CI) |
P | ||
| G*01:01:02 | IU-TR vs. NT |
2.26 (1.10- 4.64) |
0.0
36 |
3.22 (1.03- 10.1) |
0.0
43 |
2.02 (0.74- 5.52) |
0.1 68 |
2.13 (0.79- 5.78) |
0.1 34 |
| G*01:01:02 | IU2-TR vs. NT |
1.68 (0.97- 2.89) |
0.0
78 |
2.39 (1.10- 5.20) |
0.0
27 |
1.54 (0.73- 3.22) |
0.2 52 |
1.79 (0.88- 3.65) |
0.1 05 |
|
G*01:01:02/G*01
:01:02 |
IU-TR vs. NT |
4.31 (0.98- 18.9) |
0.0
72 |
8.79 (1.46- 52.8) |
0.0
17 |
4.81 (1.04- 22.3) |
0.0
44 |
5.08 (1.12- 22.9) |
0.0
35 |
|
G*01:01:02/G*01
:03:01 |
IU2-TR vs. NT |
4.61 (1.17- 17.9) |
0.0
31 |
10.0 (2.15- 46.8) |
0.0
03 |
3.14 (0.73- 13.5) |
0.1 22 |
3.81 (0.89- 16.3) |
0.0 71 |
| 3187G | IU-TR vs. NT |
2.96 (1.31- 6.67) |
0.0
11 |
2.17 (0.67- 6.99) |
0.1 92 |
2.56 (0.90- 7.29) |
0.0 77 |
2.42 (0.86- 6.83) |
0.0 94 |
| 3187GG | IU-TR vs. NT |
14.4 (2.18- 94.7) |
0.0
11 |
29.6 (2.36- 371.0) |
0.0
09 |
- | - | - | - |
| 3187GG | IU2-TR vs. NT | 5.39 (0.86- 33.7) |
0.0
80 |
6.69 (0.91- 49.4) |
0.0
62 |
10.9 (1.06- 113.6) |
0.0
44 |
6.51 (1.04- 40.7) |
0.0
45 |
| UTR1 | IU-TR vs. NT |
2.96 (1.31- 6.67) |
0.0
11 |
2.17 (0.67- 6.99) |
0.1 92 |
2.56 (0.90- 7.29 |
0.0 77 |
2.42 (0.86- 6.83) |
0.0 94 |
| UTR1/UTR1 | IU-TR vs. NT |
13.3 (2.07- 85.7) |
0.0
12 |
29.6 (2.36- 371.0) |
0.0
09 |
- | - | - | - |
| UTR1/UTR2 | IU2-TR vs. NT |
3.66 (1.01- 13.3) |
0.0
52 |
5.44 (1.32- 22.4) |
0.0
19 |
3.43 (0.91- 12.8) |
0.0 67 |
3.57 (0.95- 13.3) |
0.0 58 |
| UTR3/UTR4 | IP-TR vs. NT |
8.19 (1.30- 51.5) |
0.0
34 |
6.17 (0.91- 41.4) |
0.0 61 |
4.24 (0.63- 28.5) |
0.1 37 |
N/A | N/ A |
|
| |||||||||
| Combined effect | |||||||||
|
| |||||||||
|
G*01:01:02 &
3187G |
IU-TR vs. NT |
4.12 (0.70- 24.2) |
0.1 45 |
6.62 (0.82- 52.9) |
0.0 74 |
3.81 (0.64- 22.5) |
0.1 40 |
4.19 (0.70- 24.9) |
0.1 16 |
|
G*01:01:02 or 3187G |
IU-TR vs. NT |
4.51 (1.25- 16.1) |
0.0
14 |
4.93 (1.24- 19.5) |
0.0
23 |
4.14 (1.14- 15.1) |
0.0
31 |
4.12 (1.13- 14.9) |
0.0
31 |
mVL: maternal viral load; mNVP: maternal single-dose Nevirapine; KIR2DS4-v: non-functional KIR2DS4; N/A: not an applicable adjustment, since infant possession of KIR2DS4-v has been association with IU HIV-1 transmission and not IP HIV-1 transmission. Highlighted and bold P values indicate significant differences (P<0.05).