Table 1. Clinical characteristics of matched primary and metastatic medulloblastoma in the discovery and validation cohorts.
| HuGene2.0 Gene Expression (n=9) | 450K DNA Methylation (n=11) | Validation Tissue Microarray (n=19) | ||||
|---|---|---|---|---|---|---|
|
|
||||||
| Variable | No. | % | No. | % | No. | % |
| Age, years | ||||||
| ≤ 5 | 1 | 11 | 1 | 9 | 5 | 26 |
| 5-18 | 5 | 56 | 6 | 55 | 11 | 58 |
| ≥18 | 1 | 11 | 1 | 9 | 3 | 16 |
| Unknown | 2 | 22 | 3 | 27 | 0 | 0 |
|
| ||||||
| Sex | ||||||
| Male | 3 | 33 | 4 | 36 | 10 | 53 |
| Female | 4 | 44 | 4 | 36 | 9 | 47 |
| Unknown | 2 | 22 | 3 | 28 | 0 | 0 |
|
| ||||||
| Subgroup | ||||||
| WNT | 0 | 0 | 0 | 0 | 0 | 0 |
| SHH | 1 | 11 | 1 | 9 | 4 | 21 |
| Group 3 | 2 | 22 | 3 | 27 | 8 | 42 |
| Group 4 | 6 | 67 | 7 | 64 | 7 | 37 |
| Unknown | 0 | 0 | 0 | 0 | 0 | 0 |
|
| ||||||
| Histology | ||||||
| Classic | 3 | 22 | 3 | 27 | N/A | |
| Desmoplastic | 0 | 0 | 0 | 0 | N/A | |
| Large Cell Anaplastic | 1 | 11 | 1 | 9 | N/A | |
| Unknown | 5 | 67 | 7 | 64 | N/A | |
|
| ||||||
| Died of disease | ||||||
| No | 1 | 11 | 2 | 18 | 4 | 21 |
| Yes | 4 | 44 | 3 | 27 | 15 | 79 |
| Unknown | 4 | 44 | 6 | 55 | 0 | 0 |
*
8/12 samples have both gene expression and 450K DNA methylation data