Table 1.
Microbiota-responsive traits among GWA-validated mutants.
| Gene | Wolb.b | SNP Rank in GWA |
Validated effects of microbiotac |
Number of validated effects/total tested | |||
|---|---|---|---|---|---|---|---|
| TAG | Glucose | Glycogen | Validatedd | Validated plus off-target effecte |
|||
| TAG | 2/5 | 1/4 | |||||
| Dscam3 | N | 13 | + | ||||
| mthl1a | N | 17 | + | * | |||
| Glucose | 2/4 | 1/4 | |||||
| CG32264 | N | 3 | + | ||||
| CG30288a | Y | 45 | + | * | |||
| Glycogen | 3/5 | 1/6 | |||||
| CG1688 | Y | 1 | + | ||||
| CG5565 | Y | 13 | * | + | |||
| Fili | Y | 15 | + | ||||
| TAG and Glucose | |||||||
| Rg | Y | 5,6,7 TAG | + | + | * | 2/2 | 1/1 |
| 86 glucose | |||||||
a
nonsynonymous SNP in coding region in GWA.
b
Incidence of Wolbachia, determined by diagnostic PCR of adult flies (Y, present; N, absent).
c
+, predicted effect; *, unpredicted effect.
d
Number validated genes for nutritional trait/total number of genes tested for nutritional trait
e
Number of off-target effects of genes that had GWA-predicted effects/total possible number of off-target effects of genes that had GWA-predicted effects.
Datasets showing predicted and non-predicted significant effects of mutations on microbiota-dependent nutritional traits are displayed in Supplementary Fig. 3.