Skip to main content
. Author manuscript; available in PMC: 2016 Jan 7.
Published in final edited form as: ACS Catal. 2015 Jan 7;5(4):1172–1185. doi: 10.1021/cs501704f

Scheme 2.

Scheme 2

Active site of LDH. Nicotinamide ring of NADH and pyruvate and imidazole ring of His192 (in orange) are treated quantum mechanically in all calculations. Arg105 belongs to the mobile loop.