Fig. 3. Wild-type and ΔK32 lamin A bind LAP2α in vitro and in vivo.
(A) Ponceau protein staining of bacterially expressed and blotted recombinant wild-type prelamin A, ΔK32-prelamin A, or vimentin on nitrocellulose, and autoradiogram of the same blot after probing with [35S] labelled LAP2α are shown. (B) Autoradiography of in vitro-translated [35S} labelled LAP2α separated by SDS-PAGE. (C) Immunoblots of total cell lysates of ΔK32-lamin A/C fibroblasts (5% of input) and immunoprecipitates obtained with lamin A/C antibodies or empty beads (mock).