Study participation |
6 (2–9) |
10 |
Population described for key characteristics |
1 |
2 |
Sampling and recruitment described |
2 |
2 |
Inclusion/exclusion criteria described |
1 |
2 |
Adequate participation |
2 |
2 |
Baseline study sample described |
1 |
2 |
Prognostic factor measurement |
9 (4–10) |
12 |
Prognostic factors are clearly described or defined |
2 |
2 |
Continuous variables reported, or appropriate cut-off points used |
1 |
2 |
Prognostic factors are valid and reliable |
2 |
2 |
Study sample has complete data for prognostic factors |
2 |
2 |
Same method and setting of measurement for all study participants |
2 |
2 |
Appropriate methods used for missing prognostic data |
0 |
2 |
Outcome measurement |
4 (0–6) |
6 |
Definition of the outcome described |
2 |
2 |
Outcome measure and method are valid and reliable |
1 |
2 |
Same method and setting of measurement for all study participants |
1 |
2 |
Confounding factor measurement |
8 (4–10) |
14 |
Important confounders are measured |
1 |
2 |
Clear definitions of confounders described |
2 |
2 |
Measurement of all confounders is valid and reliable |
1 |
2 |
Same method and setting of measurement for all study participants |
2 |
2 |
Appropriate methods used for missing confounder data |
0 |
2 |
Important confounders accounted for in the study design |
1 |
2 |
Important confounders accounted for in the analysis |
1 |
2 |
Analysis |
7 (4–8) |
8 |
Sufficient presentation of data to assess the adequacy of the analysis |
1 |
2 |
Strategy for model building appropriate and based on a conceptual model |
2 |
2 |
Adequate selection of model for the design of the study |
2 |
2 |
No selective reporting of results |
2 |
2 |
Median quality score of studies |
34 (24–41) |
50 |