Table 2.
Cox proportional hazard ratios and overall median survival for various tumour–node–metastasis (TNM) staging systems
| TNM stage | n (%) | Median OS, months | HR (95% CI) | P-value | |
|---|---|---|---|---|---|
| AJCC 7th edn11 | I | 33 (22%) | 70 | Referent | |
| II | 27 (18%) | 90 | 0.95 (0.42–2.11) | 0.895 | |
| III | 5 (3%) | Not reached | 0.0 (0.0–2.10) | 0.160 | |
| IVa | 61 (40%) | 32 | 2.35 (1.26–4.37) | 0.007 | |
| AJCC 6th edn21a | I | 36 (31%) | 70 | Referent | |
| II | 20 (27%) | 66 | 0.99 (0.43–2.23) | 0.975 | |
| IIIa | 17 (15%) | 41 | 1.33 (0.51–3.46) | 0.552 | |
| IIIb | 11 (9%) | 99 | 0.93 (0.31–2.81) | 0.899 | |
| IIIc | 33 (28%) | 22 | 3.31 (1.70–6.42) | <0.001 | |
| Okabayashi et al.13a | I | 40 (34%) | 79 | Referent | |
| II | 20 (17%) | 66 | 1.07 (0.47–2.43) | 0.879 | |
| IIIa | 24 (21%) | 81 | 1.46 (0.66–3.24) | 0.346 | |
| IIIb | 33 (28%) | 20 | 3.59 (1.87–6.88) | <0.001 | |
| Yamasaki12 | I | 1 (1%) | 79 | Referent | |
| II | 48 (41%) | 66 | – | – | |
| III | 32 (27%) | 81 | 1.23 (0.60–2.51) | 0.570 | |
| IVa | 36 (30%) | 20 | 3.17 (1.75–5.74) | <0.001 |
| AJCC 7th edn T (N0M0) staging | ||||
|---|---|---|---|---|
| T-stage | n (%) | Median OS, months | HR (95% CI) | P-value |
| T1 | 37 (29%) | 70 | 1.00 (referent) | |
| T2a | 14 (11%) | Not attained | 0.39 (0.10–1.38) | 0.145 |
| T2b | 26 (21%) | 41 | 1.56 (0.65–3.75) | 0.323 |
| T3 | 8 (6%) | Not attained | 0.0 | 0.182 |
| T4 | 41 (33%) | 66 | 1.6 (0.72–3.53) | 0.251 |
a
Missing staging information in nine patients.
AJCC, American Joint Committee on Cancer; CI, confidence interval; HR, hazard ratio; N0M0, node-negative and metastasis-negative disease; OS, overall survival.