Table 3.

Univariate and multivariate hazard ratios for node-negative and metastasis-negative (N0M0) patients and all patients

Variables	N0M0 patients (n = 93)					All patients (n = 126)
		n	Median survival, months	HR (95% CI)	P-value		n	Median survival, months	HR (95% CI)	P-value
Univariate analysis
Tumour size of >5 cm	Yes	58	60	1.91 (0.87–4.20)	0.102	Yes	88	38	2.50 (1.27–4.93)	0.008
	No	35	99			No	38	99
Grade 4 disease	Yes	6	14	4.23 (1.58–11.28)	0.004	Yes	10	6	3.72 (1.75–7.95)	<0.001
	No	87	81			No	116	49
Periductal invasion	Yes	28	66	1.75 (0.85–3.61)	0.123	Yes	41	38	1.61 (0.96–2.69)	0.064
	No	65	84			No	85	60
Direct invasion	Yes	11	70	0.85 (0.30–2.41)	0.762	Yes	18	43	1.21 (0.61–2.39)	0.582
	No	82	99			No	108	49
Macrovascular invasion	Yes	9	49	1.36 (0.48–3.86)	0.561	Yes	11	44	1.32 (0.60–2.89)	0.491
	No	84	81			No	115	49
Microvascular invasion	Yes	37	66	1.12 (0.57–2.17)	0.741	Yes	60	32	1.87 (1.13–3.09)	0.016
	No	56	79			No	66	70
Multiple tumours	Yes	30	81	1.40 (0.67–2.92)	0.362	Yes	38	31	1.79 (1.05–3.04)	0.031
	No	63	79			No	88	57
Positive lymph nodes	–	–	–	–	–	Yes	33	20	3.14 (1.83–5.39)	<0.001
						No	93	79
Multivariate analysis
Grade 4 disease						Yes	10	6	7.84 (3.35–18.35)	<0.001
						No	116	49
Positive lymph nodes						Yes	33	20	2.93 (1.65–5.21)	<0.001
						No	93	79
Microvascular invasion						Yes	60	32	1.85 (1.06–3.22)	0.030
						No	66	70
Multiple tumours						Yes	38	31	1.68 (0.96–2.92)	0.067
						No	88	57
Periductal invasion						Yes	41	38	1.53 (0.87–2.68)	0.136
						No	85	60
Tumour size of >5 cm						Yes	88	38	1.51 (0.75–3.06)	0.248
						No	38	99
Resection margin	–	–	–	–	–	R0	110	66	–	–
						Non-R0	16	25
Margin width	–	–	–	–	–	>5 mm	70	99		<0.001
						<5 mm	56	38

CI, confidence interval; HR, hazard ratio; N0M0, node-negative and metastasis-negative disease.