Table 2.

Regions of significant difference in functional connectivity within the default mode network between CN, aMCI−, aMCI+, and AD.

Contrast	Brain region	BA	MNI coordinates			Extent voxels (mm3)	Peak T value
			X	Y	Z
CN > aMCI+	L. lingual gyrus	18	−8	−64	2	81	4.77
CN < aMCI+	None
CN > AD	R. precuneus	7	6	−76	36	228	5.21
	L. posterior cingulate	31	−2	−40	38	112	4.49
CN < AD	None
CN > aMCI−	None
CN < aMCI−	L. precuneus	31	−20	−70	16	76	4.77
	R. superior parietal lobule	7	22	−68	58	69	4.82
	R. superior temporal gyrus	22	56	−50	14	28	3.53
	L. middle temporal gyrus	39	−48	−72	18	21	4.02
	L. culmen		0	−50	−2	18	3.79
aMCI+ < aMCI−	L. cuneus	18	−16	−74	20	383	6.32
	R. superior temporal gyrus	22	54	−48	14	51	5.75
	L. superior frontal gyrus	10	−6	64	−6	47	3.67
	R. superior parietal lobule	7	28	−66	58	30	3.10
	R. inferior temporal gyrus	21	58	−8	−18	23	4.56
	L. medial frontal gyrus	10	0	64	2	17	3.27
	Culmen		0	−62	−6	11	4.16
	R. posterior cingulate	29	4	−42	16	10	3.99
aMCI+ > aMCI−	None

CN, cognitively normal healthy control; aMCI−, amnestic-type mild cognitive impairment PiB-negative; aMCI+, amnestic-type mild cognitive impairment PiB-positive; AD, Alzheimer’s disease; BA, Brodmann area.