Table 3.
Regions of significant difference in functional connectivity within the salience network between CN, aMCI−, aMCI+, and AD.
| Contrast | Brain region | BA | MNI coordinates |
Extent voxels (mm3) | Peak T value | ||
|---|---|---|---|---|---|---|---|
| X | Y | Z | |||||
| CN > aMCI+ | None | ||||||
| CN < aMCI+ | None | ||||||
| CN > AD | None | ||||||
| CN < AD | None | ||||||
| CN > aMCI− | L. inferior frontal gyrus | 47 | −36 | 24 | −6 | 16 | 3.99 |
| CN < aMCI− | None | ||||||
| aMCI + < aMCI− | None | ||||||
| aMCI + > aMCI− | L. inferior frontal gyrus | 47 | −34 | 26 | −8 | 55 | 4.95 |
CN, cognitively normal healthy control; aMCI−, amnestic-type mild cognitive impairment PiB-negative; aMCI+, amnestic-type mild cognitive impairment PiB-positive; AD, Alzheimer’s disease; BA, Brodmann area.