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. 2015 Feb 18;10(2):e0118104. doi: 10.1371/journal.pone.0118104

Table 1. Antiproliferative properties of the synthetized compounds.

Compound Conc. (μM) Inhibition % ± SEM[Calculated IC50 value] a
HeLa MCF7 A431 MRC5
2 10 b 29.83 ± 2.36 n.d. c
30 30.24 ± 2.25 51.48 ± 1.87
3 10 n.d.
30 24.44 ± 2.51 47.71 ± 2.22
4a 10 37.44 ± 2.44 34.92 ± 0.58 n.d.
30 68.28 ± 0.54 49.93 ± 0.63 47.92 + 1.24
[10.21 μM] [>30 μM] [>30 μM]
4b 10 n.d.
30
4c 10 n.d.
30
4d 10 24.68 ± 1.31 n.d.
30 45.45 ± 0.84 28.79 ± 1.51 26.13 ± 2.30
4e 10 51.34 ± 0.62 34.13 ± 2.14 41.87 ± 1.92 n.d.
30 71.39 ±1.17 64.39 ± 1.15 55.47 ± 0.79
[14.80 μM] [17.78 μM] [22.76 μM]
4f 10 47.07 ± 1.06 61.87 ± 2.59 n.d.
30 97.30 ± 0.49 96.36 ± 0.44 29.21 ± 2.76
[10.68 μM] [8.07 μM] [>30 μM]
4g 10 n.d.
30 51.62 ± 2.04 23.24 ± 1.03
4h 10 24.19 ± 2.00 23.71 ± 1.03 n.d.
30 92.85 ± 0.41 66.63 ± 1.19 42.59 ± 1.14
[11.68 μM] [11.58 μM] [>30 μM]
4i 10 47.24 ± 2.13 26.98 ± 0.87
30 98.38 ± 0.15 82.48 ± 0.85 94.70 ± 0.46 25.74 ± 2.94
[13.85 μM] [14.88 μM] [11.75 μM] [>30 μM]
4j 10 23.78 ± 2.27 30.96 ± 1.71 35.79 ± 1.53 n.d.
30 51.49 ± 1.92 43.48 ± 1.30 49.96 ± 1.43
4k 10 25.33 ± 2.54 n.d.
30 38.09 ± 2.03 47.94 ± 1.15
4l 10 n.d.
30 34.44 ± 2.14) 33.29 ± 2.51 26.92 ± 1.75
5a 10 n.d.
30 34.63 ± 2.14 39.95 ± 1.96 52.94 ± 0.70
5b 10 40.54 ± 0.74 44.29 ± 0.73 n.d.
30 50.06 ± 1.13 44.71 ± 1.63
5c 10 n.d.
30 36.57 ± 1.08 44.20 ± 1.54 58.09 ± 0.21
5d 10 37.41 ± 1.16 26.05 ± 2.73 n.d.
30 46.76 ± 2.95 37.10 ± 2.35 49.14 ± 2.13
5e 10 31.65 ± 2.53 n.d.
30 40.81 ± 2.35
5f 10 90.47 ± 0.53 73.15 ± 1.39 72.94 ± 0.87 32.75 ± 2.49
30 95.17 ± 0.27 78.94 ± 0.55 70.98 ± 0.86 68.32 ± 0.76
[5.08 μM] [7.88 μM] [6.77 μM] [17.64 μM]
5g 10 85.62 ± 0.75 44.84 ± 2.19 47.32 ± 1.02 33.74 ± 1.74
30 95.55 ± 0.62 60.60 ± 1.97 73.60 ± 0.46 68.61 ± 1.22
[8.69 μM] [10.78 μM] [10.68 μM] [17.07 μM]
5h 10 75.26 ± 1.57 32.80 ± 2.59 43.15 ± 1.87 21.01 ± 1.58
30 86.44 ± 0.57 36.30 ± 1.26 51.76 ± 1.52 20.44 ± 1.29
[12.11 μM] [>30 μM] [>30 μM] [>30 μM]
5i 10 n.d.
30 24.55 ± 2.69 64.62 ± 1.71
5j 10 n.d.
30 40.47 ± 2.39
5k 10 26.28 ± 1.23 n.d.
30 34.55 ± 1.61
5l 10 n.d.
30 26.54 ± 2.16 –)
Cisplatin 10 42.61 ± 2.33 53.03 ± 2.29 88.54 ± 0.50 72.30 ± 2.30
30 99.93 ± 0.26 86.90 ± 1.24 90.18 ± 1.78 70.65 + 1.34
[12.43 μM] [9.63 μM] [2.84 μM] [4.51 μM]

a Mean value from two independent determinations with five parallel wells, standard deviation less than 15%.

b Inhibition values <20% are not presented for clarity.

c n.d.: not determined.