Figure 4.

Pyrimidine biosynthesis pathways predicted in E. lausannensis and related chlamydia. The pathway for the biosynthesis of UMP from PRPP and amino-acids appears to be absent in E. lausannensis. Green arrows indicate enzyme reactions predicted to be catalyzed by proteins encoded in the genome of E. lausannensis. Red arrows indicate reactions catalyzed by enzymes that could be discovered in the genome. Colored boxes indicate the presence of an enzyme catalyzing the reaction in four other members of the Chlamydiales order.