Table 3.
Reported dosages of sedatives administered in studies of sedation in NIV (compiled from Scala [9] )
| Drug | No. of patients | Dosage | Sedation target range |
|---|---|---|---|
| Dexmedetomidine | 41 | 1 μg/kg (bolus); 0.2-0.7 μg/kg/h (infusion) | RSS 2-3; RASS 2-4; BIS >85 |
| Midazolam | 41 | 0.05 mg/kg (bolus); 0.05-0.1 mg/kg/h (infusion) | RSS 2-3; RASS 2-4; BIS >85 |
| Remifentanil | 38 | 0.025-0.1 μg/kg/min (infusion) | RSS 2-3 |
| Propofol | 43 | 0.4 μg/mL (target serum concentration; step-down to 0.2 μg/mL) | OAAS/S 3-4 |
The information in this Table is derived from references 10-17. See also Table 2 of this review.
BIS, bispectral index; OAAS/S, Observer’s Assessment of Alertness/Sedation Scale, RASS, Richmond Agitation and Sedation Scale; RSS, Ramsey Sedation Scale.