Table 2.
Expression of EGFR, p-ERK1/2, p-STAT3, ERCC1, and Akt by immunohistochemistry, and clinicopathological characteristics in 96 patients with lung adenocarcinoma.
| Group | EGFR mean score | P value | pERK1/2 positivity (%) | P value | p-STAT3 positivity (%) | P value | p-Akt positivity (%) | P value | ERCC1 positivity (%) | P value |
|---|---|---|---|---|---|---|---|---|---|---|
| Sex | ||||||||||
| Male | 122.4 | 0.19 | 7 (7.61) | 0.5 | 14 (15.3) | 0.2 | 4 (4.3) | 0.4 | 18 (20.4) | 0.6 |
| Female | 91.0 | 7 (7.61) | 15 (16.4) | 8 (8.6) | 21 (23.8) | |||||
| Age | ||||||||||
| Below 60 years | 82.2 | 0.14 | 3 (3.2) | 0.17 | 8 (8.7) | 0.2 | 5 (5.3) | 0.8 | 12 (13.6) | 0.17 |
| Above 60 years | 177.8 | 11 (11.9) | 21 (23) | 7 (7.5) | 27 (30.6) | |||||
| Size/stage | ||||||||||
| T1 | 70.0 | 0.01 | 8 (8.7) | 0.22 | 11 (12) | 0.7 | 6 (6.4) | 0.5 | 18 (20.4) | 0.4 |
| Greater than T1 | 129.1 | 6 (6.5) | 18 (19.7) | 6 (6.4) | 21 (23.8) | |||||
| Vascular invasion | ||||||||||
| Yes | 80.1 | 0.01 | 2 (2.2) | 0.05 | 11 (12.3) | 0.9 | 2 (2.2) | 0.05 | 12 (13.9) | 0.2 |
| No | 141.7 | 12 (13.3) | 18 (20.2) | 11 (12) | 26 (30.2) | |||||
| Pleural invasion | ||||||||||
| Yes | 90.4 | 0.07 | 2 (2.2) | 0.3 | 8 (8.9) | 0.5 | 1 (1.1) | 0.1 | 10 (11.6) | 0.7 |
| No | 142.1 | 13 (13.9) | 21 (23.6) | 11 (12) | 28 (32.5) | |||||
| High grade histology | ||||||||||
| Yes | 155.5 | <0.01 | 3 (3.2) | 0.5 | 9 (9.8) | 0.6 | 5 (5.3) | 0.3 | 13 (14.7) | 0.5 |
| No* | 84.4 | 11 (11.9) | 20 (21.9) | 7 (7.5) | 26 (29.5) |
*Predominantly solid or acinar cribriform tumors (high grade) versus other subtypes.