Table 1.
This table depicts the new malignancy grading system of oral squamous cell carcinoma patients as proposed by Anneroth et al. (1986) [6] and Bryne et al. (1989 and 1991) [7, 8].
| Morphologic parameter | Histological grading of malignancy of tumor cell population | |||
|---|---|---|---|---|
| 1 | 2 | 3 | 4 | |
| Degree of keratinization | Highly keratinized (>50% of the cells) | Moderately keratinized (20–50% of the cells) | Minimal keratinization (5–20% of the cells) | No keratinization (0–5% of the cells) |
|
| ||||
| Nuclear polymorphism | Little nuclear polymorphism (>75% mature cells) | Moderately abundant nuclear polymorphism (50–75% mature cells) |
Abundant nuclear polymorphism (25–50% mature cells) | Extreme nuclear polymorphism (0–25% mature cells) |
|
| ||||
| Number of mitoses/HPF | 0-1 | 2-3 | 4-5 | >5 |
|
| ||||
| Pattern of invasion | Pushing well-delineated infiltrating borders | Infiltrating, solid cords, bands and/or strands | Small groups or cords of infiltrating cells (n > 15) | Marked and wide spread cellular dissociation in small groups of cells (n < 15) and/or in single cells |
|
| ||||
| Lymphoplasmacytic infiltration | Marked | Moderate | Slight | None |