Table 4.
SULT1A1 genetic variants and risk of lung, bladder and colorectal cancer.
| Author, year | Cancer type | Population | Cases/controls (n) | Main finding | References |
|---|---|---|---|---|---|
| Liao, 2012 | Lung | Mixed | 1669/1890 | Significant association between SULT1A1*2 and lung cancer risk NA between smokers and non-smokers |
Liao et al. (2012) |
| Ihsan, 2011 | Lung | Indian | 188/290 | Significant association with risk | Ihsan et al. (2011) |
| Tamaki, 2011 | Lung | Japanese | 192/203 | NA | Tamaki et al. (2011) |
| Arslan, 2009 | Lung | Turkish | 106/271 | Significant association with risk | Arslan et al. (2009) |
| Pachouri, 2006 | Lung | North Indians | 103/122 | Significant association with increasing SULT1A1*1 alleles | Pachouri et al. (2006) |
| Huang, 2009 | Bladder | Taiwanese | 112 cases | SULT SNPs might modify the arsenic methylation profile and UC progression | Huang et al. (2009) |
| Figueroa, 2008 | Bladder | Spanish Bladder Cancer Study | 1150/1149 | NA after adjusting for age, gender, region, and smoking status between SULT1A1 and bladder cancer | Figueroa et al. (2008) |
| Wang, 2008 | Bladder | Taiwanese | 300/300 | Significantly increased risk with SULT1A1* 1 in ever smokers and heavy smokers (≥28 pack-years) | Wang et al. (2008b) |
| Kellen, 2007 | Bladder | Belgians | 200/385 | Increased risk with SULT1A1*1 in ever exposure by false-positive report probability | Kellen et al. (2007) |
| Kellen, 2006 | Bladder | Belgians | 200/385 | NA | Kellen et al. (2006) |
| Fortuny, 2006 | Bladder | Spaniards | 958/1029 | NA | Fortuny et al. (2006) |
| Zhang, 2011 | Colorectal | 12 study meta-analysis | 3549/5610 | NA | Zhang et al. (2011) |
| Cleary, 2010 | Colorectal | Canadian (Ontario Familial Colorectal Cancer Registry) | 1174/1293 | Increased risk with SULT1A1*1 in smokers. | Cleary et al. (2010) |
| Cotterchio, 2008 | Colorectal | Canadian (Ontario Familial Colorectal Cancer Registry) | 842/1251 | SULT1A1*2 significantly modified the association between red meat doneness intake and CRC risk | Cotterchio et al. (2008) |
| Fan, 2007 | Colorectal | Chinese | 207 w/sporadic CRC | Gene–gene interaction between CYP1B1 1294G & SULT1A1*1 | Fan et al. (2007) |
| Lilla, 2007 | Colorectal | German | 604/505 | CRC risk elevated with frequent consumption of red meat + carriers of SULT1A1*2 allele CRC risk elevated with 30+ pack-years of active smoking + carriers of SULT1A1*2 allele |
Lilla et al. (2007) |
NA: no association.