. 2014 Nov 18;12(1):287–297. doi: 10.1021/mp5006867

Table 1. Sensitivity of Platinum-Sensitive and -Resistant Cell Lines to TriplatinNC after 72 h Exposure As Tested by Growth Inhibition Assays; Resistance (RI) Values for TriplatinNC and Cisplatin Are Reported^a.

cell line	p53 status	TriplatinNC IC₅₀ (μM)	TriplatinNC RI	cisplatin RI
IGROV-1	wt	3.6 ± 0.7
IGROV-1/Pt1	mutant	5.1 ± 1.7	1.4	12.2
IGROV-1/CP	mutant	2.9 ± 0.7	0.79	8.3
IGROV-1/OHP	mutant	7.4 ± 2.3	2.0	8.2
H460	wt	3.9 ± 1.3
H460/Pt	wt	2.0 ± 0.4	0.5	2.6
A549	wt	4.6 ± 0.9
A549/Pt	wt	2.8 ± 0.9	0.6	4.8
A2780	wt	2.7 ± 0.9
A2780/CP	wt	3.4 ± 1.1	1.2	4.0
U2-OS	wt	7.0 ± 3.5
U2-OS/Pt	wt	5.5 ± 0.7	0.78	5.0

RI; resistance index. IC₅₀ resistant cells/IC₅₀ sensitive cells.

Table 1. Sensitivity of Platinum-Sensitive and -Resistant Cell Lines to TriplatinNC after 72 h Exposure As Tested by Growth Inhibition Assays; Resistance (RI) Values for TriplatinNC and Cisplatin Are Reporteda.