Figure 1.

Stylized illustrations showing (A) a diwalled molecular umbrella exhibiting molecular amphomorphism and a molecular umbrella–polar drug conjugate in an exposed and shielded conformation in an aqueous and lipophilic environment, respectively, and (B) a hypothetical “needle and thread” transport mechanism. In these illustrations, the filled and unfilled rectangles that are directly attached to each other are the hydrophobic and hydrophilic faces of an amphiphilic wall, respectively. For this work, the polar drug will be a siRNA.