Table 2.
Summary of genotyped and imputed SNPs associated under chr15q21.2-22.3
| Gene/Nearby Gene1 | SNP rs# | Position (bp) | MA | MAF Case/Control | OR | 95% CI
|
P-Value | |
|---|---|---|---|---|---|---|---|---|
| Lower | Upper | |||||||
|
| ||||||||
| MYO1E | rs747722 | 59599222 | T | 0.34/0.24 | 4.41 | 2.29 | 8.50 | 9.07x10−6 |
| MYO1E | rs28394564 | 59599606 | G | 0.34/0.24 | 4.41 | 2.29 | 8.50 | 9.07x10−6 |
| MYO1E | rs28673219 | 59599996 | A | 0.34/0.24 | 4.24 | 2.21 | 8.16 | 1.47x10−5 |
| MNS1||ZNF280D | rs55780277 | 56866974 | T | 0.43/0.51 | 0.30 | 0.17 | 0.53 | 2.23x10−5 |
| NEDD4 | rs138585173 | 56239500 | A | 0.14/0.09 | 8.00 | 3.03 | 21.10 | 2.67x10−5 |
| MYO1E | rs8034553 | 59598008 | T | 0.33/0.24 | 4.12 | 2.12 | 7.99 | 2.83x10−5 |
| MYO1E | rs747721 | 59598381 | G | 0.33/0.24 | 4.12 | 2.12 | 7.99 | 2.84x10−5 |
| MYO1E | rs16941266 | 59596619 | C | 0.33/0.23 | 4.04 | 2.09 | 7.81 | 3.41x10−5 |
| MNS1||ZNF280D | rs3858886 | 56824818 | A | 0.25/0.32 | 0.34 | 0.20 | 0.56 | 3.88x10−5 |
| MYO1E | rs28583561 | 59597454 | G | 0.33/0.23 | 3.93 | 2.02 | 7.62 | 5.23x10−5 |
| MNS1||ZNF280D | rs57287820 | 56844596 | A | 0.29/0.22 | 3.69 | 1.93 | 7.08 | 8.23x10−5 |
BP-base pair (GRCH37.p13/hg19); MA-minor allele; MAF-minor allele frequency; OR-odds ratio; CI-confidence interval
1
Nearby genes, noted with//, are the closest genes to the associated SNP regardless of distance