Figure 1.

Relationship between the ratio of TBW/IBW and dose-normalized IHL-305 sum total AUC (AUC/dose). AUC/dose in patients aged <60 and ≥60 years are represented by the solid triangles and open triangles, respectively.

Notes: The best-fit line of the data is represented by the curved solid line (R²=0.12). After controlling for age, there was an inverse relationship between TBW/IBW and AUC/dose, with a low TBW/IBW being associated with high AUC/dose in patients aged <60 years; CPT-11 is irinotecan; IHL-305 is a PEGylated liposomal formulation of irinotecan.

Abbreviations: AUC, area under the concentration versus time curve; TBW/IBW, total body weight to ideal body weight.