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. 2015 Feb 10;10:1201–1209. doi: 10.2147/IJN.S62911

Figure 2.

Figure 2

Relationship between two factors, age, and the ratio of TBW/IBW, and ratio of released CPT-11 AUC to sum total CPT-11 AUC.

Notes: Patients are divided into four groups according to the median value of age and TBW/IBW. The size of each circle correlates with ratio of released CPT-11 AUC to sum total CPT-11 AUC in a patient at the specific age and ratio of true body weight to ideal body weight. The mean ± standard deviation values for the ratio of released CPT-11 AUC to sum total CPT-11 AUC were 0.0042±0.0028, 0.0038±0.0038, 0.0066±0.0084, and 0.0025±0.0013 in patients aged <60 years and TBW/IBW <1.16, patients aged ≥60 years and TBW/IBW <1.16, patients aged ≥60 years and TBW/IBW ≥1.16, and patients aged <60 years and TBW/IBW ≥1.16, respectively; CPT-11 is irinotecan; IHL-305 is a PEGylated liposomal formulation of irinotecan.

Abbreviations: AUC, area under the concentration versus time curve; TBW/IBW, total body weight to ideal body weight.