Figure 3.

Relationship between percent decrease in monocytes and dose normalized CPT-11 AUC (AUC/dose).

Notes: (A, B) Represent the relationship between percent decrease in monocytes and AUC/dose in patients with linear clearance and nonlinear clearance, respectively. The relationship between AUC/dose and percent decrease in monocytes was best described by a linear relationship in patients with linear clearance (P=0.008, y = −0.108x +14.7, R²=0.49); CPT-11 is irinotecan; IHL-305 is a PEGylated liposomal formulation of irinotecan.

Abbreviation: AUC, area under the concentration versus time curve.