Figure 4.

Relationship between percent decrease in monocytes and age in all patients with a dose ≥50 mg/m².

Notes: For patients with a dose ≥50 mg/m² and ≤88 mg/m², individual values are represented by the solid circles. For patients with a dose ≥120 mg/m², individual values are represented by the open triangles. There was a linear relationship between the percent decrease in monocytes and age in all patients (R²=0.32), patients with a dose ≤88 mg/m² (R²=0.49), and in patients with a dose ≥120 mg/m² (R²=0.43); CPT-11 is irinotecan; IHL-305 is a PEGylated liposomal formulation of irinotecan.