Table 1.

HMGB1 levels and clinicopathological parameters in patients with breast cancer

		n	Tissue HMGB1, n				Serum HMGB1
			Low	High	χ2	P-value	ng/mL	t-value	P-value
Age, years	≤50	32	9	23	0.0683	0.7938	4.84±2.31	0.7160	0.4771
	>50	24	6	18			4.36±2.76
Menopause	Yes	25	8	17	0.6261	0.4288	4.32±2.57	0.8452	0.4017
	No	31	7	24			4.89±2.46
HER-2/neu	Negative	41	12	29	0.4810	0.4879	4.42±2.40	0.9916	0.3258
	Positive	15	3	12			5.12±2.80
Tumor diameter	≤2 cm	30	10	20	1.4125	0.2346	4.51±2.55	0.4114	0.6824
	>2 cm	26	5	21			4.79±2.49
Axillary lymph node metastasis	Negative	31	12	19	5.0344	0.0248*	4.34±2.36	0.9878	0.3277
	Positive	25	3	22			5.00±2.67
Differentiation grade	High	18	10	8	11.1957	0.0008*	4.17±2.51	0.9148	0.3644
	Intermediate/low	38	5	33			4.83±2.51
TNM stage	0, I, II	37	13	24	3.8766	0.0490*	4.55±2.41	0.3596	0.7206
	III, IV	19	2	17			4.81±2.73

Note:

^*P<0.05.

Abbreviations: TNM, tumor-node-metastasis; HMGB1, high mobility group box-1.