TABLE 1.
Mean Bias and Relative SD of Fitted Parameters Using Compartmental or Diffusion-Limited Model to Fit Simulated Diffusion-Limited Time–Activity Curves with Gaussian Noise
| Fitting model | k1 (kon) | k2 (koff) | k3 | k4 | P* | Blood volume |
|---|---|---|---|---|---|---|
| Compartmental (no priors) | ||||||
| μ | 3,100% | 1 × 106% | 2,090% | 1,660% | 63% | 13% |
| Relative SD | 76% | 180% | 910% | 860% | 61% | 28% |
| Compartmental (with priors) | ||||||
| μ | 210% | 470% | 1.5 × 104% | 1.7 × 103% | −7% | 6% |
| Relative SD | 100% | 200% | 340% | 500% | 16% | 42% |
| Diffusion (no priors) | ||||||
| μ | 31% | −30% | 290% | 10% | 25% | 8% |
| Relative SD | 150% | 140% | 180% | 16% | 110% | 25% |
| Diffusion (with priors) | ||||||
| μ | 1% | −20% | 210% | 4% | 6% | −6% |
| Relative SD | 46% | 110% | 170% | 8% | 18% | 3% |
*
P is capillary permeability.
Data shown are percentage of true parameter values (for mean) and percentage of mean fitted value (for relative SD).