TABLE 2.

Parameter Values for Measured Time–Activity Curves from Both Mice Using Both Compartmental and Diffusion Models with Bayesian Priors

Model	kon (M·s)−1	koff (s)−1	k3 (s)−1	k4 (s)−1	P* (m/s)	Blood volume	Ag† (nM)	D (µm2/s)
Compartmental (mouse 1)	4.1 × 104	5.3 × 10−4	7.7 × 10−6	5.1 × 10−6	4.4 × 10−9	0.17	1,031	Not applicable
Diffusion
Mouse 1	1.6 × 105	2.1 × 10−4	1.1 × 10−5	6.9 × 10−6	3.7 × 10−9	0.16	140	9
Mouse 2	1.8 × 105	4.4 × 10−4	2.6 × 10−5	8.1 × 10−6	3.7 × 10−9	0.10	161	10
Percentage difference between compartmental and diffusion models	−74%	152%	−30%	−26%	19%	6%	646%	Not applicable

^*P is capillary permeability.

^†Ag is steady-state antigen receptor concentration.