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. Author manuscript; available in PMC: 2015 Feb 19.
Published in final edited form as: Neurobiol Aging. 2009 Aug 31;32(7):1273–1285. doi: 10.1016/j.neurobiolaging.2009.08.003

Figure 5.

Figure 5

Bar graphs show performance of the same APP+PS1 (black bars) and NTg mice (open bars) mice shown in Figure 4 re-tested for transfer and reversal learning at 12 mo. Panel (A) shows errors to criterion (mean ± S.E.M) in the concurrent discrimination learning and panel (B) shows percent error (mean ± S.E.M) in the transfer phase of the task. No significant differences were observed in errors to criterion (mean ± S.E.M) during initial discrimination learning (A); however, a significant and robust deficit in transfer learning was observed in APP+PS1 mice at this age. In contrast, the reversal learning deficit observed at young ages (Fig. 4C) was not observed when aged mice were re-tested using a novel problem at 12 mo (C). See text for statistical analyses.