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. Author manuscript; available in PMC: 2015 Feb 19.
Published in final edited form as: Behav Brain Res. 2009 Jan 8;200(1):48–59. doi: 10.1016/j.bbr.2008.12.036

Figure 4.

Figure 4

Dopamine profiles used in the simulations. A). In healthy controls (HC), the background level is 1. The phasic rise for reward is to 1.6 and the phasic dip for disappointment is 0.7. B) To simulate PD Off the background level is reduced to 0.8 to reflect the reduction in dopaminergic neurons. The phasic rise for reward is of a similar proportion to HC, producing a lower absolute level of 1.3. Similarly, the phasic dip for disappointment is of a similar proportion, to 0.6. C). In PD On, the tonic dopamine level is restored to the HC level by L-Dopa. The phasic rise to reward is proportionately reduced to 1.4, simulating reduced capacity in the disease state. The phasic dip to disappointment is also reduced, simulating a decreased dopamine clearance.