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Effect of tonic dopamine on model MSN. (A). Increasing the tonic dopamine level further hyperpolarizes the membrane potential in the down state. (B). Increasing the tonic dopamine level increases the plateau membrane potential in the up state. The plateau membrane potential was measured 200ms after the start of excitation. (C). Decreasing the tonic dopamine level increases the minimum excitation frequency necessary to elicit an action potential when the neuron is in the down state.
