Table 3.
Genotypic and allelic frequencies of single nucleotide polymorphisms in malaria (+) and malaria (−) groups
| Studied polymorphisms | Malaria (+) (n = 73) | Malaria (−) (n = 194) | OR (95% CI) | * P value | |
|---|---|---|---|---|---|
| IFNG + 874 T/A | |||||
| Genotypes | A/A | 38 (52%) | 101 (52.1%) | 1.00 | 0.92 |
| A/T | 30 (41.1%) | 77 (39.7%) | 0.97 (0.55-1.70) | ||
| T/T | 5 (6.8%) | 16 (8.2%) | 1.20 (0.41-3.51) | ||
| Alleles | A | 106 (73%) | 279 (72%) | 0.16 (0.68 - 1.58) | 0.87 |
| T | 40 (27%) | 109 (28%) | |||
| NOS2A-952G/C | |||||
| Genotypes | G/G | 70 (95.9%) | 183 (94.3%) | 1.00 | 0.6 |
| G/C | 3 (4.1%) | 11 (5.7%) | 1.40 (0.38-5.18) | ||
| C/C | - | - | - | ||
| Alleles | G | 143 (98%) | 377 (97%) | 1.39 (0.38 - 5.05) | 0.6 |
| C | 3 (2%) | 11 (3%) | |||
| IL10A-1082G/A | |||||
| Genotypes | A/A | 3 (4.1%) | 40 (20.6%) | 1.00 | 0.0009 |
| G/A | 64 (87.7%) | 135 (69.6%) | 0.16 (0.05-0.53) | ||
| G/G | 6 (8.2%) | 19 (9.8%) | 0.24 (0.05-1.05) | ||
| Alleles | A | 70 (48%) | 215 (62%) | 0.74 (0.50 - 1.08) | 0.12 |
| G | 76 (52%) | 173 (45%) | |||
| IL10A-592A/C and IL10A-819 T/C | |||||
| Genotypes | C/C | 13 (17.8%) | 70 (36.1%) | 1.00 | 0.0002 |
| A/C; T/C | 36 (49.3%) | 100 (51.1%) | 0.52 (0.26-1.04) | ||
| A/A; T/T | 24 (32.9%) | 24 (12.4%) | 0.19 (0.08-0.42) | ||
| Alleles | C | 62 (42%) | 240 (62%) | 0.45 (0.30 - 0.67) | 0.0001 |
| A/T | 84 (58%) | 148 (38%) |
IFNG + 874 T/A, NOS2A-954G/C, IL10A-1082G/A, IL10A-592A/C and IL10A-819 T/C polymorphisms: Alleles, n (%); Genotypes n (%); OR (95% CI), calculating odds ratios with confidence interval (CI) of 95%; *Analysis by χ2 test using the Fisher model codominance.