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. Author manuscript; available in PMC: 2015 Nov 14.
Published in final edited form as: Microbiol Spectr. 2014 Nov 14;2(6):1–22. doi: 10.1128/microbiolspec.MDNA3-0024-2014.

Figure 5.

Figure 5

PFV intasome structures. (A) Structure containing 19 bp pre-cleaved U5 DNA end (94, 207) (pdb code 3OY9). The inner integrase monomers of the tetramer, which contact the viral DNA, are painted cyan and green; the outer integrase molecules are yellow. The transferred DNA strands with CAOH 3′ ends are painted magenta whereas the non-transferred strands are orange. The large grey spheres are NTD-coordinated zinc; small grey spheres are Mn atoms coordinated by the DDE active site residues (red sticks) and viral DNA end. (B) Structure of the TCC (98) (pdb code 3OS1). Although a 30 bp target DNA (tDNA) was utilized during crystallization, only 18 bp (grey plus strand sequence -7GCACGTG\CTAGCACGTGC10) was resolved in the electron density maps.