Table 1. Diseases with significant ERC at a 5% false discovery rate.

Mean ERC	P-value	Q-value	Ngenes	Disease
0.870	< 0.00001	0.00002	3	Monilethrix
0.655	< 0.00001	0.00002	5	Spherocytosis
0.550	< 0.00001	0.00002	4	Cranioectodermal dysplasia
0.344	< 0.00001	0.00002	17	Complement deficiency
0.210	< 0.00001	0.00002	15	Fanconi anemia
0.188	< 0.00001	0.00002	14	Thrombophilia
0.183	< 0.00001	0.00002	16	Ichthyosis
0.130	< 0.00001	0.00002	24	Cataracts related genes
0.109	0.00002	0.00031	26	Mitochondrial complex deficiency
0.103	0.00024	0.00289	23	Immunodeficiency disorders
0.297	0.00024	0.00289	6	Hemolytic uremic syndrome
0.529	0.00039	0.00406	3	Bronchiectasis
0.273	0.00054	0.00496	6	Diamond-Blackfan anemia
0.507	0.00059	0.00522	3	Cornelia de Lange syndrome
0.503	0.00065	0.00550	3	Elliptocytosis
0.498	0.00070	0.00571	3	Hyperglycinuria
0.498	0.00070	0.00571	3	Iminoglycinuria
0.265	0.00077	0.00599	6	Homocysteine related disorders
0.050	0.00089	0.00656	65	Deafness
0.374	0.00104	0.00721	4	Thalassemia
0.048	0.00114	0.00760	69	Mental retardation
0.114	0.00130	0.00827	16	Leigh syndrome
0.451	0.00163	0.00961	3	Dysfibrinogenemia
0.174	0.00171	0.00991	9	Arrhythmogenic right ventricular dysplasia
0.134	0.00187	0.01047	12	Epidermolysis bullosa
0.145	0.00292	0.01494	10	Usher syndrome
0.160	0.00313	0.01574	9	Melanoma
0.143	0.00320	0.01600	10	Systemic lupus erythematosus
0.117	0.00511	0.02255	12	Ciliary dyskinesia
0.205	0.00531	0.02315	6	Pseudohypoaldosteronism
0.243	0.00561	0.02402	5	Aicardi-Goutieres syndrome
0.159	0.00565	0.02413	8	Muscular dystrophy-dystroglycanopathy
0.297	0.00576	0.02444	4	Paragangliomas
0.288	0.00711	0.02899	4	Asphyxiating thoracic dystrophy
0.124	0.00840	0.03302	10	Renal cell carcinoma
0.120	0.01023	0.03827	10	Malaria Susceptibility/Resistance
0.218	0.01093	0.04014	5	Thyroid dyshormonogenesis
0.265	0.01114	0.04069	4	Pituitary hormone deficiency
0.345	0.01195	0.04276	3	Maple syrup urine disease
0.075	0.01358	0.04666	18	Blood group genes