Fig 7. Increased anentropic specificity of SIV-specific CD8 T cell responses between weeks 5 and 20 after SIVΔnef vaccination.

The response conservation index, a measure of the CD8 T cell response weighted negatively for entropy, increases for every animal between weeks 5 and 20 (p = 0.0156). The response conservation index for an animal at a given time point is calculated as${\displaystyle \sum _{i=0}^n{F}_i}(1-E_i)$, where F is the frequency of each epitope-specific CD8 T cell response as a fraction of the total magnitude of the response, E is the entropy of the epitope, and n is the number of epitope-specific CD8 T cell responses.