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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Biochim Biophys Acta. 2014 Dec 10;1854(2):146–155. doi: 10.1016/j.bbapap.2014.12.003

Fig. 1.

Fig. 1

Model of the DGD active site. The three subsites discussed in the text are labeled as A, B, and C. The alignment of the Cα-CO2− bond with the p orbitals of the conjugated π system (Schiff base and pyridine ring) when it is in the A subsite stabilizes negative charge as it develops on Cα in the transition state. This is the stereoelectronic effect referred to in the text.