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. 2015 Feb 18;13:35. doi: 10.1186/s12916-015-0272-0

Table 1.

Specific heart failure patient subgroups representing a challenge for the implementation of LCZ696 in clinical practice

Clinical characteristics Marginally low blood pressure
Hospitalization for AHF
NYHA IV class
Advanced heart failure
Drug therapy-related characteristics ACEi-naïve patients
Intolerance to ACEi or ARB
Low ACEi dose
High ACEi dose
Patients on ARBs therapy

ACEi, angiotensin converting enzyme inhibitors; ARB, angiotensin receptor blockers; NYHA, New York Heart Association.